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362 Although nutlins have promising antitumor activity in tumors expressing wild-type p53, they have not been used in clinical applications because of their toxicity and poor bioavailability

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Statements Author contributions All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis, and interpretation, or in all these areas - that is, revising or critically reviewing the article

systolic blood pressure down 6-9 mmHg, reversing on withdrawal: Sattar Ann Rheum Dis 2026